Worst missed opportunity in a classic line - Data's final line
At the end, in a climactic moment, Data says "Resistance is futile!" and smashes the coolant tank.
The script writer was obviously trying to be ironic or something - what an idiot. The Borg weren't resisting Data, he (and the rest of the crew) were resisting the Borg.
The line should have been:
"Resistance is NEVER futile."