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Johnny Depp. He's a train wreck.

Ashton Kutcher
Bill Cosby
Tyler Perry
Shia The Beef
Randy Quaid
Lena Dunham

Robert Francis, for two reasons:

1) He was the most wooden actor to ever appear on screen.
2) He's dead. I don't personally have anything against hiring dead people, but the problems with the union mean it's just not worth it. Those folks at the Dead Actors Guild are a bunch of assholes.

Most of what people have posted so far boil down to a matter of personal taste of acting styles. I'll throw in some names based on empirical experience:

Tom Sizemore. Completely unreliable and erratic on a good day. Sometimes he shows up ready to work, but his drug problems are too well-documented to ignore.

Damon Wayans. Despite being hilarious in front of the camera, once footage isn't rolling he can be a rude prick to cast members and crew.

James Corden. Asshole of the highest order. The lower someone his below him on the pecking order, the worse they get treated.

Anne Hathaway. I have an inkling that in the years she's amassed tons of success and awards she's learned to treat whom she views as "the little people" with a modicum of humanity, but to me she'll always be a duplicitous cunt.

Terrence Howard. His professional attitude is decent enough, but the guy is a space case. https://youtu.be/nbrFHcueCMw?t=52

Lindsay Lohan because of her unprofessional behaviour (being late and no-shows).

I’ve been hearing that Gina Carano is nothing but trouble.

I wouldn't hire anyone who is left leaning and spreads their message to the world. You can have your lefty views but if you are a social justice warrior I don't want to help increase your fame.

Debra Messing
Michael Shannon