Jim Parson's voice doesn't suit the role
I feel like it sounds wrong. Like the "Wrong Sounding Muppets" gag from Family Guy.
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No, not at all. Sheldon has a hard time understanding the emotions of those around him. Oh, on the other hand, was very aware of others' emotions and expressed emotions himself. Sheldon is fine with less contact with people. Oh craved the company of others and was very social, even if his attempts just failed.