My top 10 favorite guest stars on Will and Grace:
1. Gene Wilder
2. Lily Tomlin
3. Molly Shannon
4. Minnie Driver
5. Britney Spears
6. Alec Baldwin
7. Ellen Degeneres
8. John Cleese
9. Leslie Jordan
10. James Earl Jones
These were the most memorable and funniest guest stars IMO. What are yours?
Sandra Bernhard and Matt Damon. Two really hilarious episodes.
[deleted]
Matt Damon
Jeff Goldblum
and if he's considered a guest star, then Harry Connick Jr.
Agh! I totally forgot Kevin Bacon! Loved that!
I haven't watched the show in about 7 years, until my DVR recently recorded Matt Damon's episode (because he's one of the actors my DVR is set to auto-record), which was always one of my favorites episodes. I'm sure I'm forgetting many other guest stars that I enjoyed.