Would Laura Marry Urkel in Real Life?
IMHO, no marriage because he would've remained in the friend zone.
Laura marries a normal guy whom she divorces after a few kids and years. Urkel becomes slightly less nerdy and has a happy long-lasting marriage to a sweet woman. Urkel and Laura remain supportive friends forever. Perhaps their children fall in love and marry which would be nice.
I wouldn't mind seeing a spin-off, but Jaleel White has likely moved on from the character. Maybe a TV movie?