For sure Blair couldn't have been acting crazy as the Thing; that behaviour wasn't displayed by the monster any other time. If anything, it would have just slipped away quietly. It could've holed up somewhere with a good excuse ("I need to analyze this material") No, Blair didn't get turned until they left him in the shed - one of the group's dumbest moves.
What they should have done with him was waited for him to run out of steam (tired) and then reasoned with him, or asked him what strategy he wanted to do and followed it. Of course, they couldn't be sure he wasn't the Thing so their paranoia made them choose a different action.
That paranoia is, of course, the main point here, and what kills them is their own mistrust in one another. The logical thing to do would be to only ever stay in the same room, as a group. Vote on everything. That way there is no leader (who might be a Thing) and the Thing is never isolated enough to attack. You arm as many people as possible so if any one person turns, all the others are aware of it.
After that, you come up with tests (like the hot needle test) and you find out who's who. You do this in a sealed room so the Thing can't escape, only get killed once you find out (inevitably) who it is. Ideally, you'd clear out the furniture beforehand, too.
Burn the body.
You test everybody every hour after having burned the Thing. You do this all night. After that, get some shuteye in halves (ie, three awake, three asleep), and keep testing every (say) four hours or so. You can slowly dial back the testing (once a day, once a week, and so on) just to be on the safe side. But I'd say if nobody's a Thing by one month out, it ain't happening.
Write a full report, redundant copies, get those to civilization. Meanwhile, check around to see if there are any more ships.
Of course, all of that is reliant on people not flipping out on each other. Even Mac, the most reliable member of the team, lets paranoia get the best of him at points, and that's what kills them. They're doomed by a lack of faith in each other.
Yeah, it can't be one or two cells. Maybe like in virology small amounts would be suppressed by the immune system, no matter how camouflaged. Could someone develop an immunity to the Thing...?
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