The Four Horsemen of Apocalypse
I'm really surprised it seems no one got this already (maybe inside any threads?) but each one of the main characters plays a Bible Horseman. Patrick Wilson is Pestilence, Richard Jenkins is Hunger, Kurt Russell is War and Matthew Fox is Death. It's quite subtle, but the hints are in the first half o the film. To add more religious layers, there are other subtle references as "all I see is a snake on a tree", a reference to the original sin.
I'm half through the movie - didn't catch it, in theaters - and I couldn't resist checking this out...