From the ending of Covenant, I reckon a portion of the other 2000 colonists will wake up early from cryosleep, and will cause Covenant to crash back at LV-223 again. Daniels and Tennessee will either die in crash, or will have died inbetween movies from being facehuggered.
Now with David and other awoken colonists on LV-223 again, they will come across the Xenomorph birthed at the end of Prometheus. This Xenomorph turns out to be a Queen, and has been there laying eggs, and the eggs have impregnated the deceased corpses of the humans who died in Prometheus. This Xenomorph cannot be controlled by David like the ones in Covenant, so a battle between David's first ABANDONED creations and David's PERFECTED creations will occur.
David will realize the Prometheus Queen is the perfect species, and the movie will end with David taking off on another Derelict ship from LV-223 with the Prometheus Queen's eggs in the cargo bay, wearing the Space Jockey suit. As he takes off, his creations and the Prometheus Queen will have or will die from fighting each other, and they'll kill off the human characters. While flying the derelict, David has what he thinks to be one of HIS engineered facehugger embryos inside of him, but somehow in a grand mistake (which is a first and final for David), he swallowed a Facehugger embryo from the Prometheus Queen, and this embryo will burst out of him, and causing him to crash on LV-426. This embryo will evolve into a Queen, and will wind up being the Queen seen in James Cameron's Aliens.
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