I don't think that the Dean Ziegler charactor would make it in a stand alone story. He needed the other charactors in this story to support him. Don't get me wrong, I would watch it, but I don't think it would be as good as one thinks it would be.
Yes he could stand alone, obviously with other characters. JCR killed it and I've actually rewatched this movie ONLY fast forwarding for the "Deanzie" parts.