This Will Be Weak and Boring.
I can see it now.
The main characters are ugly and wimpy looking. So, they will look ridiculous.
There's a lot of negativity about the 1984 version, which is a cult classic. That film attempted to capture the weirdness of the setting. It has been criticized for it.
However, the Dune story is just a story, it's not about anything deep, but just a bunch of weirdness. It takes place in a super distant future where people rejected computers and started breeding people to do special tasks. That is helped by special chemicals, namely this spice from a certain planet.
That's the story!
If you don't get weird with the characters, you have a very boring story to obtain control of this spice.
I predict that if it gets too weird, people will not understand the characters because this spice stuff and breeding program is hard to explain quickly. If the characters aren't weird, it will be boring and they will seem like average people, not spice mutants, which is what they are.
Dune requires a lot of explaining, which is okay for a book, but not an action movie. So, there are ugly actors who don't look athletic and exciting and a bizarrely complex backstory, that's hard for average people to understand, and a fairly thin plot.
It's going to be terrible.