Thanks beavis.
I also found this https://screenrant.com/queens-gambit-drugs-pills-beth-tranquilizers-explained/ which explains that there is no real life tranquilizer called "xanzolam" (which it's referred to later in the series) but Newseek suggests the fictional tranquilizer is likely inspired by Librium, which is closely-related to Valium.
It goes on to say "In the novel, her initial use is described not as hallucinatory but a sedative: "It loosened something deep in her stomach and helped her doze away the tense hours in the orphanage." And this makes sense, as her friend there advises her only to use them at night.
Unfortunately none of this goes any further to answering my question, since a sedative would be more likely to suppress the heightened mental acuity that's required for chess.
I can understand (though not codone, of course) why they'd have given sedatives to the girls there. But I'd have thought that it would be far more likely that a stimulant would aid mental acuity, rather than a depressant?
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