Never been on a bike? Never left Fairville?
Pee-Wee doesn't wonder what life is like outside of Fairville, claims to not know/care what is beyond Fairville, then when he's about to get on the motorcycle he says "I have kind of limited experience on a motorcycle." Why does this movie make it seem as if the events of Big Adventure never happened? Those were both opportunities for to tie into the old film mentioning that he's traveled before, and would prefer not to becuase of everything that happened to him last time he had an "adventure", and the motorcycle cycle comment could have been him laughing and saying "I used to have a bike! Ha ha!" Instead of him being scared.
It's just out of place that they don't make reference to those events, but then he sees the snake sign and says "I hate snakes."