I think Crowley and Mark S. are gone. He got a hero's death much like Meg did. It just kind of sucks that it was overshadowed by Cas dying, because Mark's been such a big part of the show for so long, he probably deserved better.
I'm thinking Rowena and Ruth are gone too. If that's the way they chose to end her, I'm really not happy about it.
I'm thinking Cas might be gone (Unless they have Jack bring him back), but Misha isn't. I think if they wanted to give him a fresh start next year, having an AU!Cas who is darker and doesn't know Dean or Sam and who doesn't have any particular bond with them might be a way for them to go, especially since Cas kind of got his death scene in Stuck in the Middle (With You).
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