Incest
I've seen this movie so many times I don't know how I've never realized this, but wasn't Clare and Isla Fisher's character under the impression that John and Jeremy were related to them somehow? They said they were "Uncle Ned's" kids and no one was really familiar with who that was but the entire family believed them enough to let them stay at the house for the weekend. And if they were attracted to them wouldn't they think they were attracted to their second or third cousins or someone related to them through blood? Maybe that would be by marriage? I know they really weren't related but still...?
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