My thoughts. (Spoilers)

1. One of the absolute strangest films I have ever watched.
2. A hitman goes insane? Or is haunted by his past? Or is trying to save the woman he loves?...
3. Much of the film is either a dream or some form of afterlife (the ‘Lost Highway’ is some sort of existential prison the hitman can’t escape?)
4. Feels at times like an indictment against the [Hollywood] porn industry, framing the peddlers as gangsters and their stars as demons?...seducing the youth, or destroying youth?...creating voyeuristic monsters?...
5. An excuse to get Patricia Arquette naked on film (in her absolute prime, by the way)? Kind of a meta thought here.
6. Definitely a horror film — this thing is scarier than Kubrick’s “The Shining” and Friedkin’s “The Exorcist” combined (in my humble opinion).
7. Mirrors are a motif — reflection of self?...duality?... The Patricia Arquette character has a twin... We see young and old Bill Pullman... The Vampire is the only constant, and he is the one videotaping the house — the first in a series of voyeurisms...
8. I feel like this film is a warning of sorts...of the dangers of a purely voyeuristic lifestyle...for those who create and those who partake...?
9. What did the affair have to do with anything? And how did young Pullman’s Parents play into the grand scheme of things? Or young Arquette? “I’ll leave your family alone,” she said. “I don’t care anymore.” Was Arquette a home-wrecker?
10. Bookend: “Laurant is dead.” Who was Laurant? Was it Pullman, or Logia? Or?...
My theory: Lost Highway is a cautionary morality tale told through the death dreams of an emotionally shattered professional hitman who is lost in some sort of purgatorial realm, and who longs for absolution and transition to the next phase of consciousness.
Also, great film to watch alone in an empty house around three in the morning.