Have you noticed these three things? (spoilers)
1)In the very beginning, when Fred is smoking a cigarette, we can see behind him a trail of blood on the floor and some blood splattered on the walls as well.
It suggests that he actually murdered his wife right before he received his own message "Dick Laurent is dead" on the intercom. How do you explain that?.
2)When Fred talks to the mystery man for the first time and calls his own home via the mystery man's cellphone, it takes two rings for the mystery man to pick up the phone at Fred's home.
Then, in the following scene, when Fred and Renee arrives home and Fred enter home alone in order to find out if there is someone there, the phone rings twice, and it seems like someone picks it up, just like when Fred calls home from the mystery man's cellphone and the mystery man picks the phone up after two rings. What do you think of that?.
3)Just after Fred says on the intercom "Dick Laurent is dead", he then drives away in Dick Laurent's car, and the detectives are on his tail with the sirens on.
If you listen very closely at the beginning of the movie, when he receives his "Dick Laurent is dead" message on the intercom, we can actually hear the car drives away with the detectives car chasing it with the sirens on.
source:
http://hs.teknuts.com:8082/LostHighway/main.htm