As trial lawyers like to say, there isn't a scintilla of evidence that the Solomons "infected" or otherwise appropriated existing Earthling (human) bodies.
I do have the DVDs, but I can't recall the Lithgow comment you mention. Either he knows something viewers don't, or he's unclear on the concept.
The DVD releases don't have commentary from the production team, and I've never come across detailed background information from the writers' room. So I don't know if they went into specific details about the physical transformation from alien to human (and vice-versa) when creating the working "bible" that describes and explains the characters' background.
But my impression is that they created their human bodies from scratch, and picked out features from something like a catalogue or showroom (or perhaps like a web page).
The bodies are real flesh-and-blood, but temporary containers. That's true of real humans, too, but I mean that they were more like shells or cocoons that they simply shed when it's time to revert to their original "purple tube" state.
The fact that Dick uncannily resembled Mary's Sixties professor "friend" was a fluke. Or maybe the alien shapeshifter program was like Google, and compiled body types by secretly surveilling planets and collecting visual records of the inhabitants over many years, and Dick happened to pick the professor's features.
As I recall, they sort of play with the conversion idea; on the one hand, each Solomon chose their human body. On the other hand, they wind up being perplexed and confused with the outcome, from Sally's sweaty boobs to elderly Tommy winding up as a teenager. But they never even suggest that they somehow just popped into existing people, alive or dead.
It's just my guess, but I don't think the writers wanted to tap in to the frequently-used sci-fi/horror theme of predatory, parasitic aliens taking over existing human bodies; this is the stuff of "The Puppet Masters" or "The Father-Thing", but it's too dark and grim for a sitcom like "3rd Rock".
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