I always interpreted that part as a matter of Bishop being concerned about Liz's safety rather than distrusting her. He was sufficiently spooked by the codebreaker's potential that he didn't want to take any risks. Creese's wife and daughter were sitting away from the action and didn't really know anything about the machine, so they couldn't spill any beans. But Liz witnessed the machine in use, and Bishop had the foresight, which was probably honed by being on the run for so long, to see the threat it could pose to her life.
Edit -- Just saw your point about safety. After watching the scene again, I still think it was an altruistic thing, though I see where you're coming from. Bishop and Creese probably felt that Liz could be blackmailed or threatened to spill the beans on Bishop and the gang due to her closeness to Bishop. I think Creese had that smirk not out of disrespect but rather as one seasoned vet talking to another.
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