My biggest problem...
...with DePalma's Vanities is that it is way too dumbed-down, even stooping to bathroom humor in several scenes (i.e., lines about turds, yeast infections, pissing on shoes, etc.). I mean, Seth MacFarlane (the guy behind Family Guy, for those who don't know) could've easily had written the script! The party scene, in particular, where Aubrey Buffing is introduced and discloses that he has AIDS, comes off as rather tasteless (Wolfe's novel deals with this scene in a much more tasteful way).
I, for one, would like to see another adaptation of Vanities, but this time done right, with the right actors, the right director (P.T. Anderson would be perfect) and the right script. I also believe that Wolfe should be a consultant on the production this time.