Lisa in the Remake?

Agreed. You can't make this movie nowadays without all the political correctness warriors going apesh*t. If they do remake it it'll be a watered down unfunny version.

"How would they remake it?"

Ideally, by making a movie that actually fulfills (to borrow a phrase from a popular screenwriting book) the "promise of the premise". Lisa says she's going to help the boys believe in themselves so they can comfortably flirt with girls and Wyatt can stand up to Chett. Instead, what happens is she terrifies the boys with the prospect of imminent death until they suddenly stand up to mutants they know she created/summoned, and thus probably has some power over, which includes giving a minor a very large handgun (uh... great?), so that two girls latch onto them in order to avoid some major PTSD. But since all that still didn't teach the boys self-confidence when it comes to Chett, she transforms him into an ogre. Essentially, she psychologically tortures everyone. Uh... hooray?

A good remake would have her showing the boys that they're good enough, they're smart enough, and dang it, some girls will like them enough to date, if they can learn to believe in themselves and push through their fear of rejection. Using her powers, she could create interactive teaching scenarios and roleplaying exercises, teaching them to embrace their true personalities and not put on an act of what they think girls would want from them, but also how to not come across as entitled, childish dolts. She might even challenge them to take a second look at some female peers they may have overlooked, instead of setting them up with the first hotties they set their eyes on.

If all of this sounds less exciting and less outrageous than biker mutants and ogres, well... superficially, it is. It'd indeed be a writing challenge to maintain dramatic momentum through a series of safe, private teaching exercises. Going for gonzo/sci-fi outrageousness might actually be wise - but in the third act, whereas Hughes tossed reality out the window in the middle of his second act. (And the first half of the second act, the night out on the town, didn't contain much character growth, either.) Think the Harold Ramis remake of Bedazzled, which has a lot of similarities to Weird Science, and is a considerably better movie. (And goes a bit wild in its third act, to boot.)

I agree that, based on the premise alone, remaking the movie would ignite the Internet, and launch a hundred premature and hysterical think pieces. But hey, free advertising! And if the filmmakers actually wrote and made a good movie, a more intelligent and overall better movie than the one Hughes made, it could be that rare beast, a remake of a deeply flawed original, intended not only to live up to its predecessor, or just pay homage to it, but indeed intended to outshine it.

But yeah, what would be a disaster would be to make a movie as violent and juvenile as Hughes', because it's full of stuff that, for better or worse (and mostly for better, IMO), would not fly today.

My $.02. :)