I think the slayers were artifical organisms created by the Beast who seemed to be part mad-scientist. It's like the Beast found some weird, sentient, squid-like creatures from another world and implanted those into bipedal humanoid bio-constructs that the squids could operate within like a parasite. Then ouila, the Beast had his unnatural soldiers that would obey any orders. It doesn't seem that the slayers were mindless autonomons. In a one scene a slayer backs away from Ergo, who has morphed into a tiger. Fear denotes some kind of recognition of danger thus sentience and an android brain would not react in that fashion.
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