The Huston legacy continues
Four generations of great actors on film and/or television. Starting with Walter Huston, made famous by Walter's legendary son John, who was not only a great film director but performed as one of the most chilling human villains in movie history (see Roman Polanski's "Chinatown"). Meanwhile, two of John's kids, Anjelica and Danny, come into their own as critically acclaimed actors with their respective careers. And now their nephew Jack follows in their footsteps.
Probably the most long-lasting dynasty in Hollywood that I can think of, except for maybe the Coppolas.